Learn more about the Fall Armyworm Tech Prize at our upcoming webinar
Hello!
Thank you for your interest in the Fall Armyworm Tech Prize.
We thought you might be interested in joining us for a webinar on April 18, Wednesday, 1 pm GMT, to learn more about the Prize, better understand the problem of fall armyworm in Africa and explore the possibilities around digital solutions (the webinar will finish at 2.30pm GMT). Please see dial-in details at the end of the page.
Last month, the U.S. Government’s Feed the Future Initiative launched the $400,000 Fall Armyworm Tech Prize to incentivize innovative problem-solvers to find digital tools and approaches that identify, treat, and track incidence of fall armyworm in Africa. This is a global call for localized solutions that will help smallholder farmers and other value-chain actors fight back against the fall armyworm.
The prize opened on March 28, 2018 and we’re excited about the level of engagement and interest so far. Next up – join the webinar next Wednesday, spread the word, and apply for the Prize by the May 14, 2018 deadline.
In the meanwhile, tweet us a question or suggestion @FeedtheFuture, @Challenge_prize using #fallarmyworm
Looking forward to hearing from you,
The Fall Armyworm Tech Prize team
Webinar link: https://nesta.zoom.us/j/723887255
Dial-in details (for higher quality, dial a number based on your current location):
United Kingdom: +44 (0) 20 3695 0088
Meeting ID: 723 887 255
International numbers available: https://zoom.us/u/RecKI
For more information about how to join a zoom webinar, click here.
Ben Lawrence
Looking forward to the Webinar
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daptomycin, sold under the brand name cubicin among others, is a lipopeptide antibiotic used in the treatment of systemic and life-threatening infections caused by gram-positive organisms. it is a naturally occurring compound found in the soil saprotroph streptomyces roseosporus. its distinct mechanism of action makes it useful in treating infections caused by multiple drug-resistant bacteria.
daptomycin was removed from the world health organization’s list of essential medicines in 2019. the world health organization classifies daptomycin as critically important for human medicine.
medical uses
daptomycin is indicated for use in adults in the united states for skin and skin structure infections caused by gram-positive infections, s. aureus bacteraemia, and right-sided s. aureus endocarditis. it binds avidly to pulmonary surfactant, so cannot be used in the treatment of pneumonia. there seems to be a difference in working daptomycin on hematogenous pneumonia.
adverse effects
common adverse drug reactions associated with daptomycin therapy include:
cardiovascular: low blood pressure, high blood pressure, swelling
central nervous system: insomnia
dermatological: rash
gastrointestinal: diarrhea, abdominal pain
hematological: eosinophilia
respiratory: dyspnea
other: injection site reactions, fever, hypersensitivity
less common, but serious adverse events reported in the literature include
hepatotoxicity: elevated transaminases
nephrotoxicity: acute kidney injury from rhabdomyolysis
also, myopathy and rhabdomyolysis have been reported in patients simultaneously taking statins, but whether this is due entirely to the statin or whether daptomycin potentiates this effect is unknown. due to the limited data available, the manufacturer recommends that statins be temporarily discontinued while the patient is receiving daptomycin therapy. creatine kinase levels are usually checked regularly while individuals undergo daptomycin therapy.
in july 2010, the fda issued a warning that daptomycin could cause life-threatening eosinophilic pneumonia. the fda said it had identified seven confirmed cases of eosinophilic pneumonia between 2004 and 2010 and an additional 36 possible cases. the seven confirmed victims were all older than 60 and symptoms appeared within two weeks of initiation of therapy.
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procarbazine is a chemotherapy medication used for the treatment of hodgkin’s lymphoma and brain cancers. for hodgkin’s it is often used together with chlormethine, vincristine, and prednisone while for brain cancers such as glioblastoma multiforme it is used with lomustine and vincristine. it is typically taken by mouth.
common side effect include low blood cell counts and vomiting. other side effects include tiredness and depression. it is not recommended in people with severe liver or kidney problems. use in pregnancy is known to harm the baby. procarbazine is in the alkylating agents family of medication. how it works is not clearly known.
procarbazine was approved for medical use in the united states in 1969. it is on the world health organization’s list of essential medicines, the safest and most effective medicines needed in a health system. in the united kingdom a month of treatment cost the nhs 450 to 750 pounds.
medical uses
when used to treat hodgkin’s lymphoma, it is often delivered as part of the beacopp regimen that includes bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine (tradename oncovin), prednisone, and procarbazine. the first combination chemotherapy developed for hodgkin’s lymphoma (hl), mopp also included procarbazine (abvd has supplanted mopp as standard first line treatment for hl, with beacopp as an alternative for advanced/unfavorable hl). alternatively, when used to treat certain brain tumors (malignant gliomas), it is often dosed as pcv when combined with lomustine (often called ccnu) and vincristine.
dose should be adjusted for kidney disease or liver disease.
side effects
very common (greater than 10% of people experience them) adverse effects include loss of appetite, nausea and vomiting. other side effects of unknown frequency include reduction in leukocytes, reduction in platelets, reduction in neutrophils, which can lead to increased infections including lung infections; severe allergy-like reactions that can lead to angioedema and skin reactions; lethargy; liver complications including jaundice and abnormal liver function tests; reproductive effects including reduction in sperm count and ovarian failure.
when combined with ethanol, procarbazine may cause a disulfiram-like reaction in some people.
it weakly inhibits mao in the gastrointestinal system, so it can cause hypertensive crises if associated with the ingestion of tyramine-rich foods such as aged cheeses; this appears to be rare.
procarbazine rarely causes chemotherapy-induced peripheral neuropathy, a progressive, enduring, often irreversible tingling numbness, intense pain, and hypersensitivity to cold, beginning in the hands and feet and sometimes involving the arms and legs.
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chlorambucil, sold under the brand name leukeran among others, is a chemotherapy medication used to treat chronic lymphocytic leukemia (cll), hodgkin lymphoma, and non-hodgkin lymphoma. for cll it is a preferred treatment. it is given by mouth.
common side effects include bone marrow suppression. other serious side effects include an increased long term risk of further cancer, infertility, and allergic reactions. use during pregnancy often results in harm to the baby. chlorambucil is in the alkylating agent family of medications. it works by blocking the formation of dna and rna.
chlorambucil was approved for medical use in the united states in 1957. it is on the world health organization’s list of essential medicines, the safest and most effective medicines needed in a health system. it was originally made from nitrogen mustard.
medical uses
chlorambucil’s current use is mainly in chronic lymphocytic leukemia, as it is well tolerated by most patients, though chlorambucil has been largely replaced by fludarabine as first-line treatment in younger patients. it can be used for treating some types of non-hodgkin lymphoma, waldenstr?m macroglobulinemia, polycythemia vera, trophoblastic neoplasms, and ovarian carcinoma. moreover, it also has been used as an immunosuppressive drug for various autoimmune and inflammatory conditions, such as nephrotic syndrome.
side effects
bone marrow suppression (anemia, neutropenia, thrombocytopenia) is the most commonly occurring side effect of chlorambucil. withdrawn from the drug, this side effect is typically reversible. like many alkylating agents, chlorambucil has been associated with the development of other forms of cancer.
less commonly occurring side effects include:
gastrointestinal distress (nausea, vomiting, diarrhea, and oral ulcerations).
central nervous system: seizures, tremors, muscular twitching, confusion, agitation, ataxia, and hallucinations.
skin reactions
hepatotoxicity
infertility
hair loss
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doxorubicin , sold under the brand name adriamycin among others, is a chemotherapy medication used to treat cancer. this includes breast cancer, bladder cancer, kaposi’s sarcoma, lymphoma, and acute lymphocytic leukemia. it is often used together with other chemotherapy agents. doxorubicin is given by injection into a vein.
common side effects include hair loss, bone marrow suppression, vomiting, rash, and inflammation of the mouth. other serious side effects may include allergic reactions such as anaphylaxis, heart damage, tissue damage at the site of injection, radiation recall, and treatment-related leukemia. people often experience red discoloration of the urine for a few days. doxorubicin is in the anthracycline and antitumor antibiotic family of medications. it works in part by interfering with the function of dna.
doxorubicin was approved for medical use in the united states in 1974. it is on the world health organization’s list of essential medicines. versions that are pegylated and in liposomes are also available; however, are more expensive. doxorubicin was originally made from the bacterium streptomyces peucetius.
medical use
doxorubicin is commonly used to treat some leukemias and hodgkin’s lymphoma, as well as cancers of the bladder, breast, stomach, lung, ovaries, thyroid, soft tissue sarcoma, multiple myeloma, and others. commonly used doxorubicin-containing regimens are ac (adriamycin, cyclophosphamide), tac (taxotere, ac), abvd (adriamycin, bleomycin, vinblastine, dacarbazine), beacopp, chop (cyclophosphamide, hydroxydaunorubicin, vincristine, prednisone) and fac (5-fluorouracil, adriamycin, cyclophosphamide).
doxil (see below) is used primarily for the treatment of ovarian cancer where the disease has progressed or recurred after platinum-based chemotherapy, or for the treatment of aids-related kaposi’s sarcoma.
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